For me the relationship was over when he couldn't understand what I was talking about. Either I was using too big of words or too complicated ideas. It got to the point where I couldn't be myself around him. Sometimes people are mismatched and one or the other won't or can't change. Breaking it off can be the best thing for both of you.
In my case I try to saved almost all of my relationships, but it didn’t work and it has been my fault because of my following TWO HUGE ISSUES:
FIRST, I have a tendency to over deliver specially in the beginning, too caring, expensive gifts, anything that I might think it would make my boyfriend feels super special!!
SECOND, I have tooooooo much patience and hold down most dislikes.
Because of the above, all my past relationships had the same pattern, I call it the "Funnel", and it consist in the wide part for him and the narrow part for me. The problem is that with time obviously I´m getting tired little by little because it’s pretty obvious the uneven terms of the relationship so at one point I try to ask for changes but they had always been late thus by the time things are different I´m already disappointed and had loss all interest.
So in summary in the future I´ll try to save my boyfriend from me!!! :DD